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A free online tool for protein cleavage sites prediction with a chosen enzyme.
Calculate monoisotopic and average mass of a custom peptide or peptides predicted from a protein.
The cleavage specificities of selected enzymes.
A comprehensive and freely accessible resource of protein sequence and functional information.
Mass spectrum simulation tool for peptide/protein sequences. The number of charge can be custom defined.
An online tool predicts m/z values for SMS ions generated from selected fragmentation methods such as CID, ECD, or ETD. The ion type and maximum number of charge can be pre-defined.
PDB provides the most complete collection of information about the 3D structures of proteins, protein complexes and other biomolecules.
Useful links
Antibody biosimilar analysis Service
Therapeutic antibodies and biosimilars are very complex biomolecules with thousands of atoms arranged into a defined but dynamic three-dimensional structure. The unique higher-order structure (HOS) is essential for them to function properly, and a misfolded structure can be ineffective and/or cause unpredictable toxicity to patients. Therefore, during the antibody and biosimilar drug development process, not only their primary structure (amino acid sequence) needs to be accrately characterized, but also their higher-order structure.
From intact antibody molecular weight determination to drug conjugation site determination and fingerprint-like higher-order structure (HOS) comparative assessments, NovoAb provides a complete service package for antibody/ADC characterization and biosimilar characterization. Our HDX-MS comparability data with 100% sequence coverage provides complete structural information that covers the whole antibody/biosimilar, without any missed regions or residues (read more about our technology here). This unique feature provides unparalleled confidence in assessing the higher-order structural similarity of different antibodies/ADCs. Our HOS assessments are performed according to FDA/EMA guidelines and our results have been used for regulatory filling application. No matter your sample is a small therapeutic protein or whole antibody/biosimilar or PEGylated biologics, we have a tailored solution to meet your needs. Read more about HOS characterization here.
Key features:
- Accurate MW assay for mAb, ADC, biosimilars, fusion proteins
- Complete peptide mapping
- Fast paratope mapping
- High-resolution higher-order structural (HOS) similarity assessment
- Receptor binding comparability assessment
- Precise drug conjugation site determination
- Disulfide mapping
- PTM profiling including glycosylation
- Minimized mg sample requirements
- Comprehensive report
