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If you have a question or need a quotation for your project using one of our services, please just fill out the Inquiry Form on the "Contacts" page, and we will do our best to respond to your inquiry within 24 hours.

PeptideCutter

A free online tool for protein cleavage sites prediction with a chosen enzyme.

 

PeptideMass

Calculate monoisotopic and average mass of a custom peptide or peptides predicted from a protein.

 

Enzyme Preferences

The cleavage specificities of selected enzymes.

 

UniProt

A comprehensive and freely accessible resource of protein sequence and functional information.

 

MS-Isotope

Mass spectrum simulation tool for peptide/protein sequences. The number of charge can be custom defined.

 

MS-Product

An online tool predicts m/z values for SMS ions generated from selected fragmentation methods such as CID, ECD, or ETD. The ion type and maximum number of charge can be pre-defined.

 

Protein Data Bank

PDB provides the most complete collection of information about the 3D structures of proteins, protein complexes and other biomolecules.

Useful links

Antibody screening by HDX+AI

 

Screening antibodies by epitope at scale and high-resolution is sometimes desirable. NovoAb’s new HDX+AI FineMapping platform is specifically developed for this purpose. It is an integration of high-throughput HDX-MS measurements with our novel deep learning based, information-driven in silico computing technology Aibind. This ground-breaking technology can quickly map the epitopes of hundreds of antibodies in days, rather than weeks to months, at single amino acid resolution to atomic resolution, and has a much higher success rate (>99.9%) than traditional docking softwares. It can accurately generate high-resolution binding map of the antibody-antigen complexes, so you will get both the epitope and paratope information at a resolution like in Crystallography. It also dramatically lowered the cost of epitope/paratope mapping.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

To quickly screen numerous antibody candidates against a specific (or cross-reactive) epitope for the development of broadly neutralizing antibodies (bnAbs) against a virus, NovoAb also developed the TASTE technology platform (depicted below), which significantly reduces the turnaround time of our epitope mapping service.  It is applicable to antigens such as Hemagglutinin of influenza, E protein of Zika, and Spike protein of the new coronavirus. We successfully identified an effective cross-reactive epitope for SARS-Cov-2 in 2021.

 

 

 

 

 

 

 

 

 

 

 

 

 

Key features:­

  • Fast & Cost-effective
  • High-throughput
  • Any antibody format (mAb, Fab, scFv, IgM, IgA etc.)

  • Any protein target

  • Works for both linear and conformational epitopes
  • Glycosylated epitopes
  • Highly dynamic antigens
  • Minimal sample requirements

  • Free cross-reactive epitope identification