Contact us

If you have a question or need a quotation for your project using one of our services, please just fill out the Inquiry Form on the "Contacts" page, and we will do our best to respond to your inquiry within 24 hours.

PeptideCutter

A free online tool for protein cleavage sites prediction with a chosen enzyme.

 

PeptideMass

Calculate monoisotopic and average mass of a custom peptide or peptides predicted from a protein.

 

Enzyme Preferences

The cleavage specificities of selected enzymes.

 

UniProt

A comprehensive and freely accessible resource of protein sequence and functional information.

 

MS-Isotope

Mass spectrum simulation tool for peptide/protein sequences. The number of charge can be custom defined.

 

MS-Product

An online tool predicts m/z values for SMS ions generated from selected fragmentation methods such as CID, ECD, or ETD. The ion type and maximum number of charge can be pre-defined.

 

Protein Data Bank

PDB provides the most complete collection of information about the 3D structures of proteins, protein complexes and other biomolecules.

Useful links

HDX-MS Service

 

Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS) is one of our key technologies used for accurate and comprehensive antibody protein structural characterization. Our HDX-MS service platform is founded on the technologies developed by our senior scientists for over a decade, and we continually develop innovative methodologies and proprietary workflows for our services. Here at NovoAb we have three different HDX-MS strategies, namely "bottom-up HDX-MS", "top-down HDX-MS" and "middle-down HDX-MS" to meet your needs. One or a combination of two of the strategies can be chosen based on the objective of your specific project. Below is a schematic overview of our HDX-MS technologies.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

From protein conformational change to high-resolution higher-order structure (HOS) assessment, antibody epitope mapping and paratope mapping, and drug binding site determination, NovoAb offers tailored CRO services using individual or combined bottom-up HDX-MS, top-down HDX-MS, and the newest middle-down HDX-MS assays. We avoid the uncertainties caused by high level of back exchange through the use of subzero temperature UHPLC technologies. Read more here.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Key features:

  • 100% sequence coverage for mAb

  • Minimized back exchange by subzero temperature LC-MS

  • High resolution up to single-residue by SEED technology

  • Tailored assay using bottom-up, top-down, or middle-down HDX-MS

  • Enhanced coverage for glycosylated proteins

  • Accurate protein binding site determination

  • Higher-order structure comparison

  • High resolution protein conformational change